Regena Cassandrra (born Regina Cassandra) is an Indian actress and model who works predominantly in Telugu and Tamil cinema alongside Hindi and Kannada productions. Born on December 13, 1990, in Madras (present-day Chennai), Tamil Nadu, she completed her schooling in Chennai and earned a Bachelor of Science (B.Sc.) in Psychology from Women's Christian College, Chennai, followed by a Master of Science in Counseling Psychology from the University of Madras. Having started in the entertainment industry as a child anchor at the age of nine for the children's television channel Splash, she made her acting debut at age sixteen in the Tamil romantic comedy *Kanda Naal Mudhal* (2005). After completing her higher education and appearing in several acclaimed short films, she made her Kannada debut in K. M. Chaitanya's *Suryakaanti* (2010). She achieved an immediate commercial breakthrough in Telugu cinema with Tatineni Satya's *Siva Manasulo Sruthi* (*SMS*, 2012), which won her the SIIMA Award for Best Female Debut – Telugu. Cassandrra rapidly established herself as one of Telugu cinema's most popular and versatile leading ladies, headlining consecutive commercial hits including *Routine Love Story* (2012), Pandiraj's Tamil comedy *Kedi Billa Killadi Ranga* (2013), Maruthi's *Kotha Janta* (2014), *Ra Ra... Krishnayya* (2014), K. S. Ravindra's action blockbuster *Power* (2014) opposite Ravi Teja, and A. S. Ravi Kumar Chowdary's *Pilla Nuvvu Leni Jeevitham* (2014) alongside Sai Dharam Tej. She continued demonstrating her screen presence in high-profile projects such as Harish Shankar's *Subramanyam for Sale* (2015), *Rajathandhiram* (2015), the acclaimed romantic comedy *Jyo Achyutananda* (2016) which earned her a SIIMA Best Actress nomination, and Lokesh Kanagaraj's hyperlink thriller *Maanagaram* (2017). Known for fearlessly taking on complex and grey-shaded characters, she delivered standout performances in Prasanth Varma's psychological ensemble *Awe!* (2018), Venkat Ramji's mystery thriller *Evaru* (2019), and Selvaraghavan's horror drama *Nenjam Marappathillai* (2021). She made her Hindi film debut in Shelly Chopra Dhar's coming-of-age romantic comedy-drama *Ek Ladki Ko Dekha Toh Aisa Laga* (2019) alongside Sonam Kapoor. Cassandrra garnered immense national and critical acclaim across digital streaming platforms, earning a Filmfare OTT Award nomination for her portrayal of Mridula Sarabhai in SonyLIV's biographical series *Rocket Boys* (2022–2023), headlining ZEE5's thriller series *Jaanbaaz Hindustan Ke* (2023), and starring in Raj & DK's hit Amazon Prime Video black comedy thriller series *Farzi* (2023). Her filmography extends to the action thriller *Saakini Daakini* (2022), the Tamil comedy *Conjuring Kannappan* (2023), Magizh Thirumeni's action thriller *Vidaamuyarchi* (2025) alongside Ajith Kumar, Gopichand Malineni's Hindi action film *Jaat* (2025) opposite Sunny Deol, the fantasy horror *Mookuthi Amman 2* (2025), and the Telugu thriller drama *Mareechika* (2026).
