A powerful film about serodiscordant couples (of mixed HIV status) living with HIV and AIDS. John and Noel are in a panic. The condom broke during sex, and John happens to have AIDS. Joanne breaks down when the counselor asks about her HIV-positive husband Robert. In their six-year marriage, Joanne has been tested twice a year, each time more stressful than the last. One + One takes an unflinching look at the lives of these two couples of mixed HIV status--one straight, one gay--as they navigate the physical and emotional minefield inherent in every serodiscordant relationship.