After an eventful party ends in disaster, four young adults - Raheem, a SoundCloud rapper; his girlfriend Zora, an accountant; Kurt, a couch surfer; and Owen, a casual hookup - find themselves involved in what appears to be a fatal hit-and-run. Fearing arrest, they separate to spend what may be their final hours of freedom on their own terms. Told through a series of interconnected vignettes, Little Vines Run! follows each of them as they confront guilt, fractured relationships, and the consequences of a night that may not be exactly what it seems.